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KMID : 0644120200330030060
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Journal of Oriental Gynecology
2020 Volume.33 No. 3 p.60 ~ p.79
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Review for Clinical Studies of Oriental Medicine on the Treatment of Ovarian Hyperstimulation Syndrome
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Ku Su-Jeong
Hwang Deok-Sang
Lee Jin-Moo
Lee Chang-Hoon
Jang Jun-Bock
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Abstract
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Objectives: This review plans to assess the efficacy and effectiveness of oriental medicine for the treatment of Ovarian Hyperstimulation Syndrome (OHSS) through literature research and overview.
Methods: Database searching was conducted to identify relevant randomized controlled trials (RCTs) on oriental medicine for the treatment of Ovarian Hyperstimulation Syndrome. Studies were searched from Journal of Korean Obstetrics and Gynecology, Korean Medical Database, Korean studies Information Service System, China National Knowledge Infrastructure, Cochrane library, PubMed and EmBase up to 21st May, 2020.
Results: Seventeen studies were finally selected. Fifteen studies intervened with oral Chinese herb medicine, two studies intervened with acupuncture and moxibustion. Nine studies concluded that intervention with oriental medicine significantly relieved OHSS symptoms. Three studies reporting ovary diameter, four studies reporting abdominal circumference and other four studies reporting pelvic effusion showed significant reduction compared to control groups. Six studies showed significantly shorter duration for hospitalization in intervention groups. Only one study showed significantly higher pregnancy rate. Factors related with vascular permeability and blood cell coagulation were significantly lowered in intervention groups in general.
Conclusions: From seventeen studies, oriental medicine relieved OHSS symptoms and showed treatment effectiveness. Further strictly designed studies and long-term observed studies are needed to establish evidences.
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KEYWORD
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Ovarian Hyperstimulation Syndrome, Oriental Medicine, In Vitr Fertilization, Randomized Controlled Trials
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